DRAFT
Patent Lens > Technology Landscapes > Human Telomerase Gene (cancer diagnostics and stem cell uses)

Reference List

  • Regenerative Medicine 2006. Stem Cell Information . 10-6-2006.  National Institutes of Health, U.S. Department of Health and Human Services.
  • Akimov SS, Ramezani A, Hawley TS, Hawley RG (2005) Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells. Stem Cells. 23, 1423-1433.
  • Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere Length Predicts Replicative Capacity of Human Fibroblasts. Proceedings of the National Academy of Sciences 89, 10114-10118.
  • Banik SSR, Guo C, Smith AC, Margolis SS, Richardson DA, Tirado CA, Counter CM (2002) C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity. Molecular and Cellular Biology 22, 6234-6246.
  • Barclay JY, Morris A, Nwokolo CU (2005) Telomerase, hTERT and splice variants in Barrett's oesophagus and oesophageal adenocarcinoma. Eur.J.Gastroenterol.Hepatol. 17, 221-227.
  • Bodner A, Ouellette M, Frolkis M, Holt S, Chiu C-P, Morin G, Harley C, Shay JW, Lichtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
  • Colgin LM, Wilkinson C, Englezou A, Kilian A, Robinson MO, Reddel RR (2000) The hTERTalpha Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity. Neoplasia 2, 426-432.
  • Cooke H, Smith B (1986) Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb Symp Quant Biol 51, 213-219.
  • Di Donna S, Mamchaoui K, Cooper RN, Seigneurin-Venin S, Tremblay J, Butler-Browne GS, Mouly V (2003) Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization. Mol.Cancer Res. 1, 643-653.
  • Fujiwara M, Kamma H, Wu W, Hamasaki M, Kaneko S, Horiguchi H, Matsui-Horiguchi M, Satoh H (2004) Expression and alternative splicing pattern of human telomerase reverse transcriptase in human lung cancer cells. Int.J.Oncol. 24, 925-930.
  • Fujiwara-Akita H, Maesawa C, Honda T, Kobayashi S, Masuda T (2005) Expression of human telomerase reverse transcriptase splice variants is well correlated with low telomerase activity in osteosarcoma cell lines. Int.J.Oncol. 26, 1009-1016.
  • Greider C, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413.
  • Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37, 614-636.
  • Hisatomi H, Ohyashiki K, Ohyashiki JH, Nagao K, Kanamaru T, Hirata H, Hibi N, Tsukada Y (2003) Expression Profile of a gamma-Deletion Variant of the Human Telomerase Reverse Transcriptase Gene. Neoplasia 5, 193-197.
  • Hoffman DC, Anderson RC, DuBois ML, Prescott DM (1995) Macronuclear gene-sized molecules of hypotrichs. Nucleic Acids Research 23, 1279-1283.
  • Kilian A, Bowtell DD, Abud HE, Hime GR, Venter DJ, Keese PK, Duncan EL, Reddel RR, Jefferson RA (1997) Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Human Molecular Genetics 6, 2011-2019.
  • Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
  • Kipling D, Cooke HJ (1990) Hypervariable ultra-long telomeres in mice. Nature 347, 400-402.
  • Leem S, Londono-Vallejo J, Kim J, Bui H, Tubacher E, Solomon G, Park J, Horikawa I, Kouprina N, Barrett J, Larionov V (2002) The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions. Oncogene 21, 769-777.
  • Lingner J, Cech TR (1996) Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3' overhang. Proceedings of the National Academy of Sciences 93, 10712-10717.
  • Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR (1997) Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase. Science 276, 561-567.
  • Meyerson M, Counter CM, Eaton E, Ellisen L, Steiner P, Caddle S, Ziaugra L., Beijersbergen R, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997d) hEST2, the putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization. Cell 90, 785-795.
  • Meyerson M, Counter CM, Eaton E, Ellisen L, Steiner P, Caddle S, Ziaugra L., Beijersbergen R, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997c) hEST2, the putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization. Cell 90, 785-795.
  • Meyerson M, Counter CM, Eaton E, Ellisen L, Steiner P, Caddle S, Ziaugra L., Beijersbergen R, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997a) hEST2, the putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization. Cell 90, 785-795.
  • Meyerson M, Counter CM, Eaton E, Ellisen L, Steiner P, Caddle S, Ziaugra L., Beijersbergen R, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997b) hEST2, the putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization. Cell 90, 785-795.
  • Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997e) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785-795.
  • Migliaccio M, Amacker M, Just T, Reichenbach P, Valmori D, Cerottini JC, Romero P, Nabholz M (2000) Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization. J.Immunol. 165, 4978-4984.
  • Nagao K, Katsumata K, Aizawa Y, Saito N, Hirata H, Sasaki H, Yamamoto S, Hikiji K, Koiwa T, Hisatomi H (2004) Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines. Oncol.Rep. 11, 127-131.
  • Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR (1997) Telomerase Catalytic Subunit Homologs from Fission Yeast and Human. Science 277, 955-959.
  • Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA (2004) Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotech 22, 297-305.
  • Saraste M, Sibbald PR, Wittinghofer A (1990) The P-loop -- a common motif in ATP- and GTP- binding proteins. Trends Biochem Sci 15, 430-434.
  • Shay JW, Wright WE (2005) Use of telomerase to create bioengineered tissues. Ann.N.Y.Acad.Sci. 1057, 479-491.
  • Thomson JA, Itskovitz-Elder J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cells lines derived from human blastocysts. Science 282, 1145-1147.
  • Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR (1998) Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58, 4168-4172.
  • Ulaner GA, Hu JF, Vu TH, Oruganti H, Giudice LC, Hoffman AR (2000) Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int.J.Cancer. 85, 330-335.
  • Wick M, Zubov D, Hagen G (1999) Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 232, 97-106.
  • Wright WE, Brasiskyte D, Piatyszek MA, Shay JW (96 A.D.) Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. The EMBO Journal 15, 1734-1741.
  • Yi X, White DM, Aisner DL, Baur JA, Wright WE, Shay JW (2000) An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2, 443-440.
  • Yokoyama Y, Wan X, Takahashi Y, Shinohara A, Tamaya T (2001) Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus. Molecular Human Reproduction 7, 853-857.
  • Zhang X, Soda Y, Takahashi K, Bai Y, Mitsuru A, Igura K, Satoh H, Yamaguchi S, Tani K, Tojo A, Takahashi TA (2006) Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells. Biochem Biophys.Res.Commun. 351, 853-859.
Comments (0)